Publications


Chronological List

Voleti V, Patel KB, Li W, Perez Campos C, Bharadwaj S, Yu H, Ford C, Casper MJ, Yan RW, Liang W, Wen C, Kimura KD, Targoff KL, Hillman EMC. Real-time volumetric microscopy of in vivo dynamics and large-scale samples with SCAPE 2.0. Nature Methods. 16(10):1054-62. (2019)

Anikeeva P, Boyden E, Brangwynne C, Cisse, II, Fiehn O, Fromme P, Gingras AC, Greene CS, Heard E, Hell SW, Hillman EMC, Jensen GJ, Karchin R, Kiessling LL, Kleinstiver BP, Knight R, Kukura P, Lancaster MA, Loman N, Looger L, Lundberg E, Luo Q, Miyawaki A, Myers EW, Jr., Nolan GP, Picotti P, Reik W, Sauer M, Shalek AK, Shendure J, Slavov N, Tanay A, Troyanskaya O, van Valen D, Wang HW, Yi C, Yin P, Zernicka-Goetz M, Zhuang X. Voices in methods development. Nat Methods. 2019;16(10):945-51. 

Montgomery MK, Kim S,  Dovas A, Patel K, Mela A, Humala N, Zhao H, Thibodeaux D, Shaik M, Ma Y, Grinband J, Chow D, Schevon C, Hillman EMC, Canoll P, "Glioma-induced alterations in neuronal activity and neurovascular coupling during disease progression". BioRxiv. Sep;10. (2019), equal contribution

Xu L,  Li W,  Voleti V, Hillman EMC Stuart Firestein, "Widespread Receptor Driven Modulation in Peripheral Olfactory Coding". BioRxiv. Sep;08. (2019), equal contribution

Hillman EMC, Voleti V, Li W, Yu H, “Light sheet microscopy in neuroscience”, Annu Rev Neurosci. 42:295-313 (2019).

Vaadia RD, Li W, Voleti V, Singhania A, Hillman EMC, Grueber WB. "Characterization of Proprioceptive System Dynamics in Behaving Drosophila Larvae Using High-Speed Volumetric Microscopy". Current Biology 29, 935–944 (2019) .equal contribution .

Hillman EMC, *Voleti V, *Patel K, *Li W, *Yu H, *Perez-Campos C, *Benezra SE, Bruno RM, *Galwaduge PT. “High-speed 3D imaging of cellular activity in the brain using axially-extended beams and light sheets”. Curr Opin Neurobiol. 50:190-200. (2018)

Shaik MA, Hillman EMC. “Skip the salt: your brain might thank you.”, Nat Neurosci. Feb;21(2):154-155. (News & Views) (2018)

Miller J, Wang ST, Orukari I, Prior J, Sudlow G, Su X, Liang K, Tang R, Hillman EMC, Weilbaecher KN, Culver JP, Berezin MY, Achilefu S. “Perfusion-based fluorescence imaging method delineates diverse organs and identifies multifocal tumors using generic near-infrared molecular probes.”, J Biophotonics. Apr;11(4):e201700232 (2018).

Nguyen HD, Ullmann JFP, McLachlan GJ, Voleti V, Li W, Hillman EMC, Reutens DC, Janke A, "Whole-volume clustering of time series data from zebrafish brain calcium images via mixture modeling". Stat Anal Data Min: The ASA Data Sci Journal,11:5–16. (2018)

Marcu L, Hillman EMC. “In vivo Optical Imaging / Intravital Microscopy.”, J Biophotonics. Jun;10(6-7):760-761. (2017)

Tang M, Gao G, Rueda CB, Awano T, Engelstad KM, Sanchez-Quintero M-J, Yang H, Li F, Li H, Su Q, Shetler KE, Jones L, McConathy J, Thibodeaux DN, Yu H, Seo R, Hillman EMC, Noebels JL, De Vivo DC, Monani UR, “Brain microvasculature defects and Glut1-deficiency syndrome averted by early repletion of the Glucose Transporter-1 protein”, Nature Communications, 8:14152. (2017).

Ma Y, Shaik MA, Kozberg MG, Kim SH, Portes JP, Timerman D, Hillman EMC. "Resting-state hemodynamics are spatiotemporally coupled to synchronized and symmetric neural activity in excitatory neurons." Proceedings of the National Academy of Sciences. PNAS, 113 (52)  E8463–E8471 (2016).

Kozberg MG, Hillman EMC, "Neurovascular coupling develops alongside neural circuits in the postnatal brain", Neurogenesis, 3(1): p. e1244439 (2016).

Ma Y, Shaik MA, Kim SH, Kozberg MG, Thibodeaux DN, Zhao HT, Yu H., and Hillman EMC, ‘Wide-field optical mapping of neural activity and brain haemodynamics: considerations and novel approaches’.Philos Trans R Soc Lond B Biol Sci. 371 p. 1705 (2016). ** Note CORRECTION (sorry!)

Chow DS, Horenstein CI, Canoll PD, Lignelli A, Hillman EMC, Filippi CG, Grinband J, “Glioblastoma Induces Vascular Dysregulation in Non-Contrast Enhancing Peritumoral Regions in Humans”, Am J Radiol, 206 (5), 1073-1081 (2016).

Kozberg MG, Ma Y, Kim SH, A. SM, and Hillman EMC, "Rapid postnatal expansion of neural networks occurs in an environment of altered neurovascular and neurometabolic coupling". J Neurosci, , 36(25): 6704-6717 (2016).

Kozberg M and Hillman EMC"Chapter 10 - Neurovascular coupling and energy metabolism in the developing brain", in Progress in Brain Research, H.H. Kazuto Masamoto and Y. Katsuya, Editors. Elsevier. p. 213-242. (2016)

Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EMC, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, and Zlokovic BV, "Neurovascular and Immuno-Imaging: From Mechanisms to Therapies". Proceedings of the Inaugural Symposium. Front Neurosci, 10: p. 46. (2016)

Chow DS, Horenstein CI, Canoll PD, Lignelli A, Hillman EMC, Filippi CG, Grinband J, “Glioblastoma Induces Vascular Dysregulation in Non-Contrast Enhancing Peritumoral Regions in Humans”, Am J Radiol, 206 (5), 1073-1081 (2016).

Bouchard MB, Voleti V, Mendes C, Lacefield C, Grueber W, Mann R, Bruno R, Hillman EMC“Swept, confocally aligned planar excitation (SCAPE) microscopy for ultra-fast, volumetric microscopy of behaving organisms”, Nature Photonics, 9, 113–119 (2015).

Galwaduge PT, Kim SH, Grosberg LE, Hillman EMC, "Simple wavefront correction framework for two-photon microscopy of in-vivo brain," Biomed. Opt. Express 6, 2997-3013 (2015)

Lacroix A, Toussay X, Anenberg E, Lecrux C, Ferreiros N, Karagiannis A, Plaisier F, Chausson P, Jarlier F, Burgess SA, Hillman EMC, Tegeder I, Murphy TH, Hamel E, and Cauli B, “COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex.” J Neurosci, 35(34): p. 11791-810. (2015).

Chen L, Choyke PL, Wang N, Clarke R, Bhujwalla ZM, Hillman EMC, Wang G, and Wang Y, "Unsupervised deconvolution of dynamic imaging reveals intratumor vascular heterogeneity and repopulation dynamics". PLoS One, 9(11): p. e112143, (2014).

Hillman EMC"Out for Blood", Scientific American MIND, July / Aug (2014).

Hillman EMC"Coupling Mechanism and Significance of the BOLD Signal: A Status Report", Annual Reviews, Neuroscience, 37, 161-181 (2014).

Chen BR, Kozberg MG, Bouchard MB, Shaik MA, Hillman EMC"A critical role for the vascular endothelium in functional neurovascular coupling in the brain", JAHA, 3: e000787, (2014).

Cayce JM, Bouchard MB, Chernov MM, Chen BR, Grosberg LE, Jansen ED, Hillman EMC, Mahadevan-Jansen A. "Calcium imaging of infrared-stimulated activity in rodent brain", Cell Calcium, 55 (4), 183-190(2014).

Qiu J, Baik AD, Lu XL, Hillman EMC, Zhuang Z, Dong C, Guo XE. A noninvasive approach to determine viscoelastic properties of an individual adherent cell under fluid flow. Journal of Biomechanics, 47 (6), 1537-1541 (2014).

Rayshubskiy A, Wojtasiewicz TJ, Mikell CB, Bouchard MB, Timerman D, Youngerman BE, McGovern RA, Otten ML, Canoll, PD, McKhann II GM, Hillman,EMC. "Direct, intraoperative observation of ~0.1 Hz hemodynamic oscillations in awake human cortex: Implications for fMRI." NeuroImage, 87, 323-331, (2014).

Hillman, EMC. & Kozberg, MG. "What secrets can functional MRI reveal about the developing infant brain?" Imaging in Medicine 5, 203-206, (2013).

Kozberg M, Chen BR, De Leo SE, Bouchard MB, Hillman EMC"Resolving the transition from negative to positive BOLD in the developing brain"PNAS, 110(11):4380-5 (2013).

Baik AD, Qiu J, Hillman EMC, Dong C, Guo XE. Simultaneous tracking of 3D actin and microtubule strains in individual MLO-Y4 osteocytes under oscillatory flow. Biochemical and Biophysical Research Communications. 2013;431:718-723

Amoozegar CB, Wang T, Bouchard MB, McCaslin AFH, Blaner WS, Levenson RM, Hillman EMC"Dynamic contrast enhanced optical imaging of in-vivo organ function", J Biomed Opt, 17(9), 096003 (2012)

Grosberg LE, Chen BR, Hillman EMC"Simultaneous multi-plane in-vivo non-linear microscopy using spectral encoding", Optics Letters, 37(14), 2967-2969 (2012).

Muldoon, TJ, Burgess SA, Chen BR, Ratner D, and EMC. Hillman"Analysis of skin lesions using laminar optical tomography". Biomed. Opt. Express, 3(7): p. 1701-1712 (2012).

Qiu J, Baik AD, Lu L, Hillman EMC, Zhuang Z, Dong C, Guo XE, “Theoretical Analysis of Novel Quasi-3D Microscopy of Cell Deformation”, Cel. Mol. Bioeng, 5 (2), 165-172 (2012).

Hillman EMC, Elson DS, Bigio IJ, Levenson RM, So PTC, “Advances in optics for biotechnology, medicine and surgery”, Biomed. Opt. Expr, 3 (3), pp. 531-532 (2012)

Hillman EMC, Amoozegar CB, Wang T, McCaslin AFH, Bouchard MB, Mansfield JR, Levenson RM, “In-vivo optical imaging and dynamic contrast methods for biomedical research” Phil. Trans. Royal Soc A. 369 (1955), 4620-4643 (2011).

Chen L, Chan TH, Choyke PL, Hillman EMC, Bhu-jwalla ZM, Chi CY, Wang G, Szabo Z, Wang, Y, “A Signal Deconvolution Tool for In Vivo Dynamic Contrast-enhanced Imaging of Complex Tissues”, Bioinformatics, in press (2011).

Grosberg LE, Radosevich AJ, Asfaha S, Yang X, Wang TJ, Hillman EMC"Spectral characterization and unmixing of intrinsic contrast in intact normal and diseased gastric tissues using hyperspectral two-photon microscopy" PlosOne, 6(5): e19925 (2011).

McCaslin AFH, Chen BR, Radosevich AJ, Cauli B, Hillman EMC, "In-vivo 3D morphology of astrocyte-vasculature interactions in the somatosensory cortex: implications for neurovascular coupling", J Cereb
Blood Flow Metab, 31, 795-806 (2011). (Feature Article and Cover)

Chen BR, Bouchard MB, McCaslin AFH, Burgess SA, Hillman EMC, "High-speed vascular dynamics of the hemodynamic response", Neuroimage, 54 (2), 1021-1030 (2011).

Baik AD, Lu XL, Qiu J, Huo B, Hillman EMC, Dong C, Guo XE, "Quasi-3D Cytoskeletal Dynamics of Osteocytes under Fluid Flow", Biophys J. 99 (9), 2812-2820 (2010).

Taber KH, Hillman EMC, Hurley RA, "Optical Imaging: A New Window to the Adult Brain", Neuropsychiatry Clin Neurosci. 22 (4), 357-360 (2010). (cover)

Nordstrom RJ, Almutairi A, Hillman EMC"Feature Issue Introduction: Bio-Optics in Clinical Applications, Nanotechnology, and Drug Discovery", Biomed Opt Expr, 1 (3), 746-747 (2010).

Burgess SA, Ratner D, Chen BR, Hillman EMC"Fiber-Optic and Articulating Arm Implementations of Laminar Optical Tomography for Clinical Applications" Biomed Opt Expr, 1 (3), 780-790, (2010).

Sun R*, Bouchard MB*, Hillman EMC "SPLASSH: Open source software for camera-based high-speed, multispectral in-vivo optical image acquisition" Biomed Opt Expr, 1 (2), 385-397 (2010). * Equal contribution first authors.

Burgess SA and Hillman EMC, "Laminar Optical Tomography", Chapter in 'Handbook of Biomedical Optics'. Eds: Boas DA, Pitris C, Ramanujam N (Taylor & Francis) (2010)

Tian P, Teng IC, May LD, Kurz R, Lu K, Scadeng M, Hillman EMC, De Crespigny AJ, D'Arceuil HE, Mandeville JB, Marota JJA, Rosen BR, Liu TT, Boas DA, Buxton R, Dale AM, Devor A, "Cortical depth-specific microvascular dilation underlies laminar differences in BOLD fMRI response", PNAS, 107 (34), 15246-15251 (2010).

Sirotin YB, Hillman EMC, Bordier C, Das A. "Spatiotemporal precision and hemodynamic mechanism of optical point-spreads in alert primates", PNAS 106, 18390-18395, (2009).

Bouchard MB*, Chen BR*, Burgess SA, Hillman EMC"Ultra-fast multispectral optical imaging of cortical oxygenation, blood flow and intracellular calcium dynamics", Optics Express, 17 (18), 15670-15678, (2009).* Equal contribution first authors. **Also selected to appear in the Virtual Journal of Biomedical Optics, 4 (10), 15670.

Hillman EMC,  Burgess SA, Chen BR. “Macroscopic molecular optical imaging of rodent brain”, Book Chapter in ‘Molecular Imaging of the Rodent Brain’ (Neuromethods Series), Editor. Bacskai B. J, Ed. In press 2009, Human Press (Springer).

Culver JP, Drexler W, Drezek RA, Georgakoudi I, Hillman EMC, Richards-Kortum R, "Topics in Biomedical Optics: introduction to the feature issue", Appl. Opt, 48 (10), TBO1-TBO2

Blaner WS, O’Byrne SM, Wongsiriroj N, Kluwe J, D’Ambrosio D, Jiang H, Schwabe RF, Hillman EMC, Piantedosi R, Libien J. “Hepatic Stellate Cell Lipid Droplets: A Specialized Lipid Droplet for Retinoid Storage”, Biochimica et Biophysica Acta, 1791(6):467-73 (2009).

Yuan B, Burgess SA, Iranmahboob AK, Bouchard MB, Lehrer N, Bordier C, Hillman EMC"System for rapid, simultaneous, high resolution, depth-resolved fluorescence and absorption optical imaging", Rev. Sci. Instrum. 80, 043706-1 (2009). *Also selected to appear in the Virtual Journal of Biological Physics Research.

Karagiannis A, Gallopin T, David C, Battaglia D, Geoffroy H, Rossier J, Hillman EMC, Staiger J, Cauli B. “Classification of NPY-expressing neocortical interneurons", J. Neurosci, 29(11):3642-3659 (2009).

Hillman EMC, Burgess SA. "Sub-millimeter Resolution 3D Optical Imaging of Living Tissue using Laminar Optical Tomography", Laser & Photonics Reviews, 3 (1-2), 159-180, (2009). 

Devor A, Hillman EMC, Tian P, Waeber C, Teng I. C, Ruvinskaya S, Shalinsky M, Zhu H, Haslinger R, Narayanan S, Ulbert I, Dunn AK, Lo E, Rosen BR, Dale AM, Kleinfeld D, Boas DA, “Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex", J. Neurosci, 28: 14347-14357 (2008).

Burgess SA, Bouchard MB, Yuan B, Hillman EMC“Simultaneous Multi-Wavelength Laminar Optical Tomography"Optics Letters, 33 (22), 2710-2712 (2008). *Also selected to appear in the Virtual Journal of Biomedical Optics, 4 (1), 2710.

Radosevich AJ, Bouchard MB, Burgess SA, Chen BR, Hillman EMC“Hyper-spectral in-vivo two-photon microscopy of intrinsic fluorophores”, Optics Letters, 33 (18), 2164-2166, (2008).*Also selected to appear in the Virtual Journal of Biomedical Optics, 3 (11), 2164 (cover) and the Virtual Journal of Biological Physics Research

Hillman EMC, Bernus O, Pease E, Bouchard MB. Pertsov A. “Depth-resolved optical imaging of transmural electrical propagation in perfused heart”, Optics Express, 15 (26), 17827-17841, 2007. *Also selected to appear in the Virtual Journal of Biomedical Optics, 3 (1), 17827 (cover) and the Virtual Journal of Biological Physics Research

Hillman EMC and Moore A. "All-optical anatomical co-registration for molecular imaging of small animals using dynamic contrast"Nature Photonics, 1 (9), 526 - 530, 2007.

Hillman EMC“Optical Brain Imaging In-vivo: Techniques and Applications from Animal to Man”[Invited Review] J Biomed Opt, 12(5), 051402 (2007). *Also selected to appear in the Virtual Journal of Biological Physics Research

Hillman EMC, Devor A, Bouchard M. B, Dunn A. K, Krauss GW, Skoch J, Bacskai J, Dale A. M, Boas D. A. “Depth-resolved Optical Imaging and Microscopy of Vascular Compartment Dynamics During Somatosensory Stimulation”, NeuroImage, 35(1): 89-104 (2007)  Supplementary Data

Devor A, Tian P, Nishimura N, Teng IC, Hillman EMC, Narayanan S. N, Ulbert I, Boas D. A, Kleinfeld D, Dale A. M. “Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative BOLD”, J Neurosci, 27(16): 4452-4459. (2007) Supplementary Data

1999-2006

Custo A, Wells W. M, Barnett A. H, Hillman E. M. C, Boas D. A, "Effective Scattering Coefficient of the Cerebral Spinal Fluid in Adult Head Models for Diffuse Optical Imaging", Appl Opt. 45(19): 4747-4755 (2006).

Zhang Q, Brukilacchio T. J, Li A, Stott J. J, Chaves T, Hillman E. M. C, Wu T, Chorlton M. A, Rafferty E, Moore R. H, Kopans D. B, Boas D. A, "Co-registered Tomographic X-ray and Optical Breast Imaging: Initial Results.", J Biomed Opt, 10(2), 024033-1-9 (2005).

Corlu A, Choe R, Durduran T, Lee K, Schweiger M, Arridge S. R, Hillman E. M. C, Yodh A. G, "Diffuse optical tomography with spectral constraints and wavelength optimization.", Appl Opt, 44(11), 2082-2093 (2005)

Li A, Boverman G, Zhang Y, Brooks D, Miller E. L, Kilmer M. E, Zhang Q, Hillman E. M. C, Boas D. A, "An optimal linear inverse solution given multiple priors in diffuse optical tomography.", Appl Opt, 44(10), 1948-1956 (2005)

Hillman, E. M. C, Boas, D. A, Dale, A. M, Dunn, A. K, "Laminar Optical Tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media", Optics Letters, 29, (14), 1650-1652 (2004).

Hillman, E. M. C, “Optical tomography”, Book chapter in 'Optics Encyclopedia', Wiley-VCH. (Released December 2003).

Corlu, A, Durduran, T, Choe, R, Schweiger, M, Hillman, E. M. C, Arridge, S. R. Yodh, A. G, "Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography”: Optics Letters, 28, 23, 2339-2341 (2003).

Hebden, J. C, Gonzalez, F. M, Gibson, A, Hillman, E. M. C, Yusof, R, Everdell, N, Delpy, D. T, Zaccanti, G, and Martelli, F, “Assessment of an in situ temporal calibration method for time-resolved optical tomography”: Journal of Biomedical Optics 8, 87-92 (2003).

Hebden,J. C, Gibson, A, Yusof, R, Everdell, N, Hillman, E. M. C, Delpy, D. T, Arridge, S. R, Austin, T, Meek, J. H, Wyatt, J. S, "Three-dimensional optical tomography of the premature infant brain”, Phys. Med. Biol , 47, 23, 4155-4166 (2002).

Hebden, J. C, Veenstra, H, Dehghani, H, Hillman, E. M. C, Schweiger, M, Arridge, S. R, and Delpy, D. T , "Three dimensional time-resolved optical tomography of a conical breast phantom", Applied Optics 40 19, 3278-3287 (2001).

Hillman, E. M. C, Hebden, J. C, Schweiger, M, Dehghani, H, Schmidt, F. E. W, Delpy, D. T, Arridge, S. R "Time Resolved Optical Tomography of the Human Forearm", Phys. Med. Biol, 46, 4, 1117-1130 (2001)

Hillman, E.M.C, Hebden,J.C, Schmidt,F.E.W, Arridge,S.R, Schweiger,M, Dehghani,H, Delpy, D.T "Calibration techniques and datatype extraction for time-resolved optical tomography", Rev Sci Instrum, 71, 9, 3415-3427 (2000).

Schmidt, F. E. W, Hebden, J. C, Hillman, E. M. C, Fry ,M. E, Schweiger,M, Delpy,D. T "Multiple slice imaging of a tissue-equivalent phantom using time-resolved optical tomography", Applied Optics 39, 19 3380-3387 (2000).

Arridge, S. R, Hebden, J. C, Schweiger, M, Schmidt, FEW, Fry, M. E. Hillman, E. M. C, Dehghani, H "A method for 3D time-resolved optical tomography". J. Imaging. Syst. Technol, 11, 2-11 (2000).

Schmidt, F.E.W, Fry, M.E, Hillman, E.M.C, Hebden, J.C, and Delpy, D.T "A 32-channel time-resolved instrument for medical optical tomography", Rev. Sci. Instrum 71, 1, 256 - 265 (2000).

Hebden, J.C, Schmidt, F.E.W, Fry, M.E, Schweiger, M, Hillman, E.M.C, Delpy, D.T, and Arridge, S. R "Simultaneous reconstruction of absorption and scattering images using multi-channel measurement of purely temporal data", Optics Letters, 24, 8, 534-536. (1999)

Elwell, C.E, Springett, R, Hillman, E.M.C, Delpy,D.T "Oscillations in Cerebral Haemodynamics - Implications for Functional Activation Studies". Adv. Exp med & Biol 471, 57-65 (1998).

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